Leptin, hs-CRP and HOMA-IR in patients with type 2 diabetes: The role of different levels of vitamin D deficiency

Salome Sadat Salehi‍, Soghra Rabizadeh, Sahar Karimpour Reyhan Reyhan Karimpour, Marjan Mouodi, Manouchehr Nakhjavani, Alireza Esteghamati, Hossein Mirmiranpour

Abstract


Background: To evaluate the effects of different levels of vitamin D deficiency on blood glucose, leptin, high sensitivity C-reactive protein (hs-CRP), and insulin resistance and their associations. 

Methods: We quantified serum vitamin D level, hs-CRP, leptin, and fasting  blood  sugar (FBS)  levels in 25 type-2 diabetic patients with deficient serum levels of 25-hydroxy vitamin D (≤15 ng/ml) and 25 type-2 diabetic patients with insufficient serum levels of 25-hydroxy vitamin D (16 to 30 ng/ml). The two groups were matched according to age, sex, and body mass index (BMI). Homeostasis model assessment of insulin resistance (HOMA-IR) was  calculated  by  a  formula based  upon  values  of  FBS and insulin concentrations.

Results: The mean value of vitamin D levels was 7.67±3.10 in the vitamin D deficient group and 23.20±9.97 in the vitamin D insufficient group. Patients with vitamin D deficiency had significantly higher FBS, postprandial glucose (PPG) and hemoglobin A1C (HbA1C) as compared to vitamin D insufficient group (p<0.01). We studied correlations of hs-CRP, HOMA-IR, and leptin in both vitamin D insufficient and deficient groups. There were significant positive correlations between leptin with hs-CRP (r = 0.58, p<0.01) and with HOMA-IR (r = 0.49, p<0.05) in vitamin D deficient group. These correlations remained significant after multiple adjustments for age, sex, BMI, systolic and diastolic blood pressure.                                                                                                                        

Conclusion: In conclusion, vitamin D deficient diabetic patients had elevated FBS, PPG and HbA1C compared with insufficient ones. The results also could possibly point the effect of vitamin D deficiency level on leptin associations with hs-CRP and insulin resistance.

Keywords: Vitamin D deficiency, type 2 diabetes, leptin, C reactive protein, homeostasis model assessment of insulin resistance  


Full Text: [Abstract] [Full Article]

DOI: 10.31989/ffhd.v9i11.661

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Copyright (c) 2019 Salome Sadat Salehi‍, Soghra Rabizadeh, Sahar Karimpour Reyhan Reyhan Karimpour, Marjan Mouodi, Manouchehr Nakhjavani, Alireza Esteghamati, Hossein Mirmiranpour

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