Effect Of Curcumin and Luteolin on Drosophila Melanogaster Transgenic Model of Parkinson’s Disease
摘要
Background:A neurodegenerative disorder called Parkinson's disease is distinguished by Lewy bodies, overexpression of α-synuclein, and dopaminergic neuron loss. Additionally, tremors, bradykinesia, and muscular rigidity are some of the disease's initial symptoms, and they are all linked to the oxidative stress that pro-oxidant reactive oxygen species create.
Objective: This investigation uses Drosophila melanogaster to assess the effects of curcumin and luteolin on a transgenic Parkinson's disease model. The study has substantial clinical value because the results might lead to the creation of cutting-edge treatments for Parkinson's disease.
Methods: Both wild-type and transgenic flies were divided into five groups. The transgenic flies were exposed to normal media, 50 mg/kg of curcumin and luteolin, and 100 mg/kg of curcumin and luteolin treatments, while wild-type flies were exposed to normal media and curcumin and luteolin (100 mg/kg) for five days. To assess the effect of curcumin and luteolin on Drosophila transgenic model of PD, we conducted experimental tests including negative geotaxis assay, catalase activities, AChE activities, fly lifespan, MDA levels, total protein, GSK3β gene expression, and total thiol levels.
Results: The transgenic flies with and without treatment expressed similar expression of the GSK3β gene, as well as a dose-dependent delay in the pattern of activity decrease, increased lifespan, higher catalase activities, increased total thiol levels, decreased MDA levels, and reduced AChE activity.
Conclusion: These findings suggest that the combination of curcumin and luteolin could serve as a supplementary approach in the treatment of Parkinson's disease.
Keywords: Parkinson’s Disease, Neurodegenerative, Lewy Bodies, Drosophila Melanogaster, Transgenic, Curcumin, Luteolin.
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