The protective effect of soybean phytochemicals on androgen responsive human prostate cancer cells LNCaP is likely mediated through modulation of hormone/cytokine-dependent pathways
DOI:
https://doi.org/10.31989/ffhd.v1i11.113Abstract
Background: Population studies suggested that consumption of a soy rich diet provides protective effects against several chronic diseases, including prostate cancer. However, the active components in soy as well as the mechanisms of action of soy’s protective effects remain unclear. It would be important to elucidate these questions to support the use of soy in the prevention of chronic disease.
Methods: A cell culture model and molecular techniques were used as tools to identify a molecular signature induced by soy-derived phytochemicals.
Results: Soy phytochemicals inhibit growth of androgen responsive prostate cancer cells. Global gene expression analysis using DNA microarray and real time PCR analysis identified multiple pathways affected by the soy-derived phytochemicals genistein, daidzein, equol, and glyceollins in the androgen responsive human prostate cancer cell LNCaP. These pathways included androgen receptor-dependent pathways, insulin-like growth factors pathways, and cell cycle-related pathways. Soy-derived phytochemicals modulated these pathways in a concentration-dependent fashion.
Conclusion: Taking into consideration the physiological achievable concentration of diet-derived soy phytochemicals, we propose the concentration-dependent cancer protective effect is likely mediated through modulation of hormone/cytokine-dependent pathways.
Downloads
Published
Issue
Section
License
Any manuscripts or substantial parts of it, submitted to the journal must not be under consideration by or previously published in any other journal or citable form. Authors are required to ensure that no material submitted as part of a manuscript infringes existing copyrights or the rights of a third party. In submitting one's article in any form, the author has assigned the FFC publishing rights and has agreed to an automatic transfer of the copyright to the publisher. This is so that the FFC may create print option journals, for example, at the FFC’s discretion. If the author wishes to distribute their works by means outside of the FFC, for example within their community, they will have to place a request.
Correspondence concerning articles published in Functional Foods in Health and Disease is encouraged. While derivative works (adaptations, extensions on the current work, etc.) are allowed, distribution of the modified material is not allowed without permission from the FFC.