In vivo anti-carcinogenic property of a formulated citrus peel extract

Authors

  • Michiko Suzawa Miyauchi Citrus Research Center, Ltd., 324-10 Shigoka-Machi, Takasaki, Gunma 370-0845
  • Limin Guo Xinjiang Academy of Agricultural Sciences, Urumqi, Xinjiang 830091
  • Min-Hsiung Pan Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 811
  • Chi-Tang Ho Department of Food Science, Rutgers University, New Brunswick, NJ 08901
  • Shiming Li Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang, Hubei

DOI:

https://doi.org/10.31989/ffhd.v4i3.21

Abstract

Background: Cancer is one of the two leading fatal diseases humans face. Synthesized drugs available for cancer intervention have many limitations in applications and effectiveness and are often associated with serious of side effects, which can further damage the patients’ quality of life.  Recently, the development of natural-product-based and therapeutically sound anti-cancer agents have gained popularity in the fields of functional and medical foods, which may exhibit advantages of minimal toxicity and multiple active molecular components. Citrus peel or its extract has been reported to have potent pharmacological activities and health benefits because of abundant flavonoids present in citrus fruits, particularly in the peels. 

Results: The results of these studies demonstrated the efficacy of Gold Lotion (GL), an extract of multiple varieties of citrus peels that contains abundant flavonoids, including a high percentage of polymethoxylflavones (PMFs), which can protect against skin cancer, colon cancer, and prostate cancer in mice.  These results are clearly promising and warrant a human trial with GL in future studies. 

Summary: Briefly, these data have demonstrated that GL is efficacious in preventing and treating cancer in several model systems. This review summarizes the results of currently available data regarding the in vivo anti-cancer activity of GL, and identifies opportunities for subsequent human clinical trials to assess preventive and therapeutic effects in the near future.

Keywords: gold lotion, citrus peel extracts, skin cancer, colon cancer, prostate cancer 

Downloads

Published

2014-03-31

Issue

Vol. 4 No. 3 (2014): March 2014

Section

Research Articles

License

Any manuscripts or substantial parts of it, submitted to the journal must not be under consideration by or previously published in any other journal or citable form. Authors are required to ensure that no material submitted as part of a manuscript infringes existing copyrights or the rights of a third party. In submitting one's article in any form, the author has assigned the FFC publishing rights and has agreed to an automatic transfer of the copyright to the publisher. This is so that the FFC may create print option journals, for example, at the FFC’s discretion. If the author wishes to distribute their works by means outside of the FFC, for example within their community, they will have to place a request. 

 

Correspondence concerning articles published in Functional Foods in Health and Disease is encouraged. While derivative works (adaptations, extensions on the current work, etc.) are allowed, distribution of the modified material is not allowed without permission from the FFC.