Mechanism Prediction of Gastro-protective Effects of the Biebersteinia multifida against Ethanol-Induced Gastric Ulcers; an Insilco study

Authors

  • Saeed Rezaei Zarchi Assistant professor, Department of Biology, Payame Noor University, Yazd, Iran
  • Mahdi Dousti Ph.D. of Pathology, Department of pathobiology, School of veterinary medicine, Shiraz University, Shiraz, Iran
  • Davood Rezazadeh Assistant Professor of Molecular Medicine. Molecular Medicine Department, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Elham Sajadi Ph.D. of Physiology, Department of Basic Science, School of veterinary medicine, Shiraz University, Shiraz, Iran.
  • Sara Rizvand MSC of Biophysics, Department of Biology, Payame Noor University, Yazd, Iran
  • Narges Eskandari Roozbahani Ph.D. Pharmacology, Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

DOI:

https://doi.org/10.31989/ffhd.v12i9.964

Abstract

Introduction: Peptic ulcer disease (PUD) is one of the most common diseases of the gastrointestinal tract. Herbal remedies are alternative therapies that have different gastro protective mechanisms, the gastro protective effect of Biebersteinia multifida (BM) was evaluated previously.

Objective: This study was performed to predict the possible mechanism of action of BM bioactive compounds on ameliorating ethanolic PUD in an Insilico study by molecular docking.

Methods: Bioactive compounds in BM were screened by Molegro Virtual Docker 6.0 (MVD) for their effects on factors affecting the healing and progression of ethanolic PUD.

Results: The principal bioactive compound in BM root that has an ameliorating effect in PUD is the flavonoids luteolin rutinoside. This compound establishes the lowest binding energy with the enzymes xanthine oxidase, cyclooxygenase-2, and superoxide dismutase, respectively.

Conclusion: Biebersteinia multifida probably affects the factors involved in ethanolic PUD due to the presence of flavonoids luteolin rutinoside and thus plays a role in the healing of PUD.

Keywords: Molecular Docking, Biebersteinia multifida, Peptic ulcer, Molegro Virtual Docker


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Published

2022-09-09

Issue

Vol. 12 No. 9 (2022): September 2022

Section

Research Articles

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