Optimal dose of Moringa oleifera Lam for hematopoietic recovery in aluminum-induced hematotoxicity
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https://doi.org/10.31989/bchd.v9i3.1944要旨
Background: Aluminum-induced hematotoxicity disrupts hematopoiesis and leads to anemia primarily through oxidative stress mechanisms. Natural antioxidants such as Moringa oleifera have shown potential protective effects; however, the optimal therapeutic dose remains unclear.
Objective: This study aimed to evaluate the dose-dependent effects of Moringa oleifera leaf extract and determine the optimal dose to improve hematological parameters in aluminum-induced hematotoxicity.
Methods: Twenty-four male Wistar rats were randomly assigned into four groups (n = 6): control, AlCl₃ + 200 mg/kg Moringa oleifera, AlCl₃ + 100 mg/kg Moringa oleifera, and Moringa oleifera (200 mg/kg) only. Hematological parameters, including hemoglobin concentration, red blood cell count, hematocrit, and differential leukocyte counts, were measured over 14 days. Statistical analysis was performed using one-way ANOVA, with p ≤ 0.05 considered significant.
Results: Treatment with Moringa oleifera significantly improved hematological parameters compared to the AlCl₃-exposed group (p ≤ 0.05). The 100 mg/kg dose demonstrated superior efficacy, with higher hemoglobin (12.00 g/dL), red blood cell count (7.23 × 10⁶/µL), and hematocrit (41.50%) compared to the 200 mg/kg dose. Additionally, an increase in lymphocyte percentage was observed. The dose-response relationship indicated a hormetic effect, where moderate dosing produced greater benefits than higher dosing.
Conclusion: Moringa oleifera exhibits significant protective effects against aluminum-induced hematotoxicity, with 100 mg/kg identified as the most effective dose. These findings highlight its potential as a natural therapeutic agent for improving hematological health under toxic conditions
Novelty of the study: This study identifies an optimal dose (100 mg/kg) of Moringa oleifera for hematological recovery in aluminum-induced toxicity and provides evidence of a hormetic dose-response effect in hematopoietic protection.
Keywords: Aluminum chloride; anemia; dose–response; erythropoiesis; Moringa oleifera; hematopoietic recovery; bioactive dose.
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コピーライト (c) 2026 Rafiah Awad Mohamed Adam, Azhari A. Mohammed Nour, Ream Hassan Ahmed, Hanan Elamin Ibrahim, Mohamad Awad Elkarim Mohamad Ibrahim, Mohammed A. Shanwaz, Wisal A. Babiker, Ibrahim Elhag Elmahdi, Soltan J. Algamdi, Abdulmajeed AA Sindi, Raed A Alharbi, Hanan E Alyahyawi, Hanan E Alyahyawi, Abdulmohsen M Alruwetei
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