Polyphenol-based antioxidant strategies for personalized prevention of hereditary cancer
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https://doi.org/10.31989/bchd.v9i4.1935摘要
Hereditary cancer syndromes, accounting for approximately 5–10% of all malignancies, are caused by germline mutations in high-penetrance genes such as BRCA1/2, TP53, and mismatch repair genes, leading to an increased risk of early-onset and aggressive cancers. Accurate prognostic biomarkers are essential for risk stratification and personalized prevention in individuals with genetic predisposition.
This review focuses on the prognostic relevance of oxidative stress and redox-dependent mechanisms in hereditary cancers. Redox imbalance, characterized by excessive reactive oxygen species (ROS) and impaired antioxidant defense, promotes genomic instability, tumor progression, and therapy resistance. Key redox-sensitive pathways, including transcription factors nuclear factor erythroid 2–related factor 2 (NRF2), nuclear factor-κB (NF-κB), and hypoxia-inducible factor-1α (HIF-1α), are discussed alongside emerging molecular and liquid biopsy biomarkers. Importantly, several dietary polyphenols, such as resveratrol, epigallocatechin gallate (EGCG), and curcumin, exhibit antioxidant, anti-inflammatory, and epigenetic effects that may help counteract mutation-associated oxidative damage. Integrating prognostic biomarker profiling with polyphenol-based, biomarker-guided functional food strategies represents a promising, non-invasive approach to personalized prevention in hereditary cancer.
Novelty of Study: This review is novel in that it integrates oxidative-stress–related prognostic biomarkers with polyphenol-based dietary interventions within the structured framework of functional food science, specifically applying the Functional Food Centre’s 17-step development model to hereditary cancer prevention, thereby proposing a biomarker-guided, personalized nutrition strategy that bridges molecular oncology and functional food applications.
Keywords: Hereditary cancer syndromes; Prognostic biomarkers; Oxidative stress; Redox signaling; dietary polyphenols; Personalized cancer prevention; Functional food science
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