Evaluation of the effect of electron beam therapy on oxidative stress and some minerals in patients with type 2 diabetes mellitus

Authors

  • Danik Martirosyan Functional Food Center, Functional Food Institute, Dallas, TX, USA
  • Fahimeh Jahanbakhshi Nano Bio Electronic Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Iran; Laser and Plasma Research Institute, Shahid Beheshti University, G.C., Thran, Iran
  • Mohammad Reza Foroughi-Gilvaee MSc, Nano Bio Electronic Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Iran
  • Fatemeh Mousavi MSc, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  • Pooya Faranoush MSc, Nano Bio Electronic Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Iran
  • Mohammad Reza Ashoori PhD, Department of Laboratory Sciences, School of Allied Medical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran
  • Masoomeh Shahnazari-Aval MSc, Department of Radio-Oncology, Cancer Institute, Valiasr Hospital, School of Medicine, Tehran University of Medical Science, Tehran, Iran
  • Afsaneh Seyed Mikaeili MSc, Department of Molecular and Cellular Sciences, Faculty of Advanced Sciences and Technology, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran
  • Hossein Mirmiranpour MD, PhD, Endocrinology and Metabolism Research Center (EMRC), Valiasr Hospital, School of Medicine, Tehran University of Medical Science, Tehran, Iran.

DOI:

https://doi.org/10.31989/ffs.v2i5.935

Abstract

Background: The study on the control and treatment of type 2 diabetes mellitus, as a growing metabolic disease in the world, is important. Oxidative stress and reactive oxygen species in uncontrolled diabetes can play a role in the consequences of diabetes such as neuropathy and nephropathy. The presence of minerals as bioactive compounds in the diet and their role in antioxidant enzymes can play a role in reducing the oxidative effects of diabetes. Electron beam therapy as an adjunct method can be effective in reducing free radicals and oxidative stress. 

Objective: The main purpose of this study was to investigate the effect of electron beam therapy on glucose, oxidative markers and some minerals, as bioactive compound, in people with type 2 diabetes mellitus. 

Methods: The study was performed on 30 volunteers with type 2 diabetes mellitus and 30 healthy volunteers as a control group. Serum samples from diabetic and control groups were assayed for glucose, hydrogen peroxide, reactive oxygen species and minerals such as iron, zinc, copper, magnesium and selenium binding protein before and after electron beam irradiation. ATP levels and NAD/NADH ratio were also evaluated. The mentioned parameters were measured by ELISA and calorimetric methods according to the relevant kit protocol. Electron beam therapy was performed using a linear accelerator. The used amount of energy was 9 MeV. The depth of treatment was 1.5 cm.

Results: The results of electron beam therapy showed that the concentrations of glucose, reactive oxygen species, hydrogen peroxide, copper and iron were significantly (P value < 0.05) reduced in diabetics. Zinc levels in this group increased significantly (P value < 0.05). In control group, ATP levels were significantly (P value < 0.05) increased by electron beam therapy.

Conclusion: According to the obtained results, electron beam therapy can be effective in reduction of oxidation indexes and thus reducing oxidative stress. Electron beam therapy can be effective in reducing the consequences of diabetes mellitus.

 

Keywords: Electron beam therapy, Oxidative stress, Mineral, Type 2 diabetes mellitus

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Published

2022-05-30

Issue

Vol. 2 No. 5 (2022): May 2022

Section

Research Articles

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