The Effects of Long-Term Ubiquinol Intake on Improving the Quality of Life of Community Residents


  • Tetsu Kinoshita Ehime University
  • Koutatsu Maruyama Juntendo University Graduate School of Medicine
  • Takeshi Tanigawa Juntendo University Graduate School of Medicine



Background: Ubiquinol is widely used as an anti-aging supplement. In this study, we evaluated the effects of long-term ubiquinol intake on improving or maintaining the quality of life (QOL) of community residents.

Methods: 124 adult (aged 22-86) residents (36 male, 88 female) participated in this trial. Each consumed 100-120 mg of ubiquinol per day for 6 months (n=22) or 12 months (n=102). We measured serum ubiquinol levels and QOL scores by SF-36 at baseline and after ubiquinol intake. 

Results: In female participants, the SF-36 scores of role physical (RP), vitality (VT), social functioning (SF), mental health (MH), and mental component summary (MCS) increased significantly. On the other hand, significant score changes were not shown in male participants. After stratifying baseline serum ubiquinol levels by tertiles, we found a significant improvement of mental QOL scores in the low and middle ubiquinol level groups of female participants, but not in the highest tertile. 

Conclusions: This trial indicates that ubiquinol supplementation has effects on female participants’ psychological QOL, especially for those whose baseline serum ubiquinol levels are in the low to middle range.

Key Words: ubiquinol, coenzyme Q10, energy production, quality of life, clinical trial 





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