Pomegranate (Punica granatum): a natural source for the development of therapeutic compositions of food supplements with anticancer activities based on electron acceptor molecular characteristics

Garth L. Nicolson, Veljko Veljkovic, Sanja Glisic, Vladimir Perovic, Nevena Veljkovic

Abstract


Background: Numerous in vitro and in vivo studies, in addition to clinical data, demonstrate that pomegranate juice can prevent or slow-down the progression of some types of cancers.  Despite the well-documented effect of pomegranate ingredients on neoplastic changes, the molecular mechanism(s) underlying this phenomenon remains elusive.

Methods: For the study of pomegranate ingredients the electron-ion interaction potential (EIIP) and the average quasi valence number (AQVN) were used. These molecular descriptors can be used to describe the long-range intermolecular interactions in biological systems and can identify substances with strong electron-acceptor properties. In this study, candidate human proteins interacting with pomegranate flavonoids have been analyzed by the informational spectrum method (ISM). This represents a virtual spectroscopy method for studying protein molecular interactions.

Results: Our analysis indicates that the anti-cancer properties of pomegranate juice can be ascribed to the strong electron-acceptor properties of its chemical ingredients. This analysis also suggests that pomegranate flavonoids inhibit the “NF-kappaB” (NF-kB) pathway, which plays a critical role in the pathogenesis of cancer.

Conclusion: The results offer a possible explanation for an important molecular mechanism underlying the anticancer activity of pomegranate ingredients, which could also serve as a basis for the development of new therapeutic compositions of food supplements with pomegranate-like anticancer properties.

Key words: cancer, pomegranate, flavonoids, food supplement, informational spectrum method


Full Text: [Abstract] [Full Article]

DOI: 10.31989/ffhd.v6i12.289

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Copyright (c) 2016 Garth L. Nicolson, Veljko Veljkovic, Sanja Glisic, Vladimir Perovic, Nevena Veljkovic

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