Syringic acid affords antioxidant protection in the pancreas of type 2 diabetic rats
DOI:
https://doi.org/10.31989/bchd.v6i2.1061Abstract
Background: Diabetes mellitus, is a multifactorial disease brought on by a complex interplay of metabolic, genetic, and lifestyle variables. Prolonged and chronic hyperglycemia is a complication of diabetes and might increase the risk of major health issues.
Objective: This investigation aims to determine whether the phenolic phytochemical syringic acid (SA) has any protective role on the pancreas of diabetic rats.
Methodology: Streptozotocin was injected intraperitoneally (40 mg/kg) into male Sprague-Dawley rats to induce diabetes. At a dosage of 50 mg per kg body weight, syringic acid (SA) was administered using an oral tube, once a day for 60 days. Our study examined plasma insulin, glucose, glycated hemoglobin, toxicity markers and antioxidant enzymes. The results were compared with those of diabetic rats receiving glimepiride (0.1 mg/kg) as the standard drug.
Results: Treatment with syringic acid significantly lowered hyperglycemia, improved insulin levels, reduced toxicity markers in diabetic rats. Further, Syringic acid also promoted activity of enzymes such as catalase, glutathione peroxidase, glutathione reductase, and superoxide dismutase in the pancreas.
Conclusion: These results imply that syringic acid, owing to its ability to control hyperglycemia, and reduce oxidative stress, affords antioxidant protection in the pancreas of diabetic rats.
Keywords: Diabetes mellitus, Syringic acid, Antioxidant protection, Glimepiride.
Veröffentlicht
Ausgabe
Rubrik
Lizenz
Any manuscripts or substantial parts of it, submitted to the journal must not be under consideration by or previously published in any other journal or citable form. Authors are required to ensure that no material submitted as part of a manuscript infringes existing copyrights or the rights of a third party. In submitting one's article in any form, the author has assigned the FFC publishing rights and has agreed to an automatic transfer of the copyright to the publisher. This is so that the FFC may create print option journals, for example, at the FFC’s discretion. If the author wishes to distribute their works by means outside of the FFC, for example within their community, they will have to place a request.
Correspondence concerning articles published in Functional Foods in Health and Disease is encouraged. While derivative works (adaptations, extensions on the current work, etc.) are allowed, distribution of the modified material is not allowed without permission from the FFC.